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MSTN Genotypes In Thoroughbred Horses Influence Skeletal Muscle Gene Expression And Racetrack Performance

MSTN Genotypes In Thoroughbred Horses Influence Skeletal Muscle Gene Expression And Racetrack Performance

MSTN Genotypes In Thoroughbred Horses Influence Skeletal Muscle Gene Expression And Racetrack Performance: This study demonstrates that myostatin may have multiple functions at different stages of development. Muscle biopsies were taken from yearling Thoroughbreds prior to the initiation of training and then following a 10-month period of training. Myostatin mRNA levels were highest in C:C horses initially, but decreased dramatically following training. It is likely that the reduction in myostatin gene expression during the course of training has a direct impact on muscle growth and development in Thoroughbred skeletal muscle.

McGivney BA, Browne JA, Fonseca RG, Katz LM, MacHugh DE, Whiston R, Hill EW. Animal Genetics. 2012 Dec;43(6):810-2.

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