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A High Density SNP Array For The Domestic Horse And Extant Perissodactyla: Utility For Association Mapping, Genetic Diversity And Phylogeny Studies

A High Density SNP Array For The Domestic Horse And Extant Perissodactyla: Utility For Association Mapping, Genetic Diversity And Phylogeny Studies

A High Density SNP Array For The Domestic Horse And Extant Perissodactyla: Utility For Association Mapping, Genetic Diversity And Phylogeny Studies: We utilized the previously generated horse genome sequence and a large SNP database to design a ~54,000 SNP assay for use in the domestic horse and related species. The utility of this SNP array was demonstrated through genome-wide linkage disequilibrium, inbreeding and genetic distance measurements within breeds, as well as multidimensional scaling and parsimony analysis.

McCue ME, Bannasch DL, Petersen JL, Gurr J, Bailey E, Binns MM, Distl O, Guérin G, Hasegawa T, Hill EW, Leeb T, Lindgren G, Penedo MC, Røed KH, Ryder OA, Swinburne JE, Tozaki T, Valberg SJ, Vaudin M, Lindblad-Toh K, Wade CM, Mickelson JR. PLoS Genetics. 2012 Jan;8(1):e1002451.

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